Host-specific exposure and fatal neurologic disease in wild raptors from highly pathogenic avian influenza virus H5N1 during the 2006 outbreak in Germany.
Identifieur interne : 000136 ( Main/Exploration ); précédent : 000135; suivant : 000137Host-specific exposure and fatal neurologic disease in wild raptors from highly pathogenic avian influenza virus H5N1 during the 2006 outbreak in Germany.
Auteurs : Judith Ma Van Den Brand [Pays-Bas] ; Oliver Krone [Allemagne] ; Peter U. Wolf [Allemagne] ; Marco W G. Van De Bildt [Pays-Bas] ; Geert Van Amerongen [Pays-Bas] ; Albert D M E. Osterhaus [Pays-Bas] ; Thijs Kuiken [Pays-Bas]Source :
- Veterinary research [ 1297-9716 ] ; 2015.
Descripteurs français
- KwdFr :
- Allemagne (épidémiologie), Animaux (MeSH), Cloaque (virologie), Encéphalite virale (anatomopathologie), Encéphalite virale (virologie), Encéphalite virale (épidémiologie), Falconiformes (MeSH), Grippe chez les oiseaux (anatomopathologie), Grippe chez les oiseaux (complications), Grippe chez les oiseaux (épidémiologie), Réaction de polymérisation en chaîne (médecine vétérinaire), Sous-type H5N1 du virus de la grippe A (physiologie), Trachée (virologie), Épidémies de maladies (médecine vétérinaire).
- MESH :
- anatomopathologie : Encéphalite virale, Grippe chez les oiseaux.
- médecine vétérinaire : Réaction de polymérisation en chaîne, Épidémies de maladies.
- physiologie : Sous-type H5N1 du virus de la grippe A.
- virologie : Cloaque, Encéphalite virale, Trachée.
- épidémiologie : Allemagne, Encéphalite virale, Grippe chez les oiseaux.
- Animaux, Falconiformes.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Animals (MeSH), Cloaca (virology), Disease Outbreaks (veterinary), Encephalitis, Viral (epidemiology), Encephalitis, Viral (pathology), Encephalitis, Viral (virology), Falconiformes (MeSH), Germany (epidemiology), Influenza A Virus, H5N1 Subtype (physiology), Influenza in Birds (complications), Influenza in Birds (epidemiology), Influenza in Birds (pathology), Polymerase Chain Reaction (veterinary), Trachea (virology).
- MESH :
- geographic , epidemiology : Germany.
- complications : Influenza in Birds.
- epidemiology : Encephalitis, Viral, Influenza in Birds.
- pathology : Encephalitis, Viral, Influenza in Birds.
- physiology : Influenza A Virus, H5N1 Subtype.
- veterinary : Disease Outbreaks, Polymerase Chain Reaction.
- virology : Cloaca, Encephalitis, Viral, Trachea.
- Animals, Falconiformes.
Abstract
Raptors may contract highly pathogenic avian influenza virus H5N1 by hunting or scavenging infected prey. However, natural H5N1 infection in raptors is rarely reported. Therefore, we tested raptors found dead during an H5N1 outbreak in wild waterbirds in Mecklenburg-Western Pomerania, Germany, in 2006 for H5N1-associated disease. We tested 624 raptors of nine species-common buzzard (385), Eurasian sparrowhawk (111), common kestrel (38), undetermined species of buzzard (36), white-tailed sea eagle (19), undetermined species of raptor (12), northern goshawk (10), peregrine falcon (6), red kite (3), rough-legged buzzard (3), and western marsh-harrier (1)-for H5N1 infection in tracheal or combined tracheal/cloacal swabs of all birds, and on major tissues of all white-tailed sea eagles. H5N1 infection was detected in two species: common buzzard (12 positive, 3.1%) and peregrine falcon (2 positive, 33.3%). In all necropsied birds (both peregrine falcons and the six freshest common buzzards), H5N1 was found most consistently and at the highest concentration in the brain, and the main H5N1-associated lesion was marked non-suppurative encephalitis. Other H5N1-associated lesions occurred in air sac, lung, oviduct, heart, pancreas, coelomic ganglion, and adrenal gland. Our results show that the main cause of death in H5N1-positive raptors was encephalitis. Our results imply that H5N1 outbreaks in wild waterbirds are more likely to lead to exposure to and mortality from H5N1 in raptors that hunt or scavenge medium-sized birds, such as common buzzards and peregrine falcons, than in raptors that hunt small birds and do not scavenge, such as Eurasian sparrowhawks and common kestrels.
DOI: 10.1186/s13567-015-0148-5
PubMed: 25879698
PubMed Central: PMC4349770
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Host-specific exposure and fatal neurologic disease in wild raptors from highly pathogenic avian influenza virus H5N1 during the 2006 outbreak in Germany.</title><author><name sortKey="Van Den Brand, Judith Ma" sort="Van Den Brand, Judith Ma" uniqKey="Van Den Brand J" first="Judith Ma" last="Van Den Brand">Judith Ma Van Den Brand</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. j.vandenbrand@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Krone, Oliver" sort="Krone, Oliver" uniqKey="Krone O" first="Oliver" last="Krone">Oliver Krone</name><affiliation wicri:level="3"><nlm:affiliation>Department Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Straße 17, 10315, Berlin, Germany. KRONE@izw-berlin.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Straße 17, 10315, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Wolf, Peter U" sort="Wolf, Peter U" uniqKey="Wolf P" first="Peter U" last="Wolf">Peter U. Wolf</name><affiliation wicri:level="1"><nlm:affiliation>Department for Diagnostic Investigation of Epizootics (LALLF), State Office for Agriculture, Food Safety, and Fishery, Mecklenburg-Western Pomerania, Rostock, Germany. Peter.Wolf@lallf.mvnet.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Diagnostic Investigation of Epizootics (LALLF), State Office for Agriculture, Food Safety, and Fishery, Mecklenburg-Western Pomerania, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Van De Bildt, Marco W G" sort="Van De Bildt, Marco W G" uniqKey="Van De Bildt M" first="Marco W G" last="Van De Bildt">Marco W G. Van De Bildt</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. m.vandebildt@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. amerongen@viroclinics.com.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. a.osterhaus@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. t.kuiken@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25879698</idno><idno type="pmid">25879698</idno><idno type="doi">10.1186/s13567-015-0148-5</idno><idno type="pmc">PMC4349770</idno><idno type="wicri:Area/Main/Corpus">000142</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000142</idno><idno type="wicri:Area/Main/Curation">000142</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000142</idno><idno type="wicri:Area/Main/Exploration">000142</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Host-specific exposure and fatal neurologic disease in wild raptors from highly pathogenic avian influenza virus H5N1 during the 2006 outbreak in Germany.</title><author><name sortKey="Van Den Brand, Judith Ma" sort="Van Den Brand, Judith Ma" uniqKey="Van Den Brand J" first="Judith Ma" last="Van Den Brand">Judith Ma Van Den Brand</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. j.vandenbrand@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Krone, Oliver" sort="Krone, Oliver" uniqKey="Krone O" first="Oliver" last="Krone">Oliver Krone</name><affiliation wicri:level="3"><nlm:affiliation>Department Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Straße 17, 10315, Berlin, Germany. KRONE@izw-berlin.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Straße 17, 10315, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Wolf, Peter U" sort="Wolf, Peter U" uniqKey="Wolf P" first="Peter U" last="Wolf">Peter U. Wolf</name><affiliation wicri:level="1"><nlm:affiliation>Department for Diagnostic Investigation of Epizootics (LALLF), State Office for Agriculture, Food Safety, and Fishery, Mecklenburg-Western Pomerania, Rostock, Germany. Peter.Wolf@lallf.mvnet.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Diagnostic Investigation of Epizootics (LALLF), State Office for Agriculture, Food Safety, and Fishery, Mecklenburg-Western Pomerania, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Van De Bildt, Marco W G" sort="Van De Bildt, Marco W G" uniqKey="Van De Bildt M" first="Marco W G" last="Van De Bildt">Marco W G. Van De Bildt</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. m.vandebildt@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. amerongen@viroclinics.com.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. a.osterhaus@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. t.kuiken@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j">Veterinary research</title><idno type="eISSN">1297-9716</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Cloaca (virology)</term><term>Disease Outbreaks (veterinary)</term><term>Encephalitis, Viral (epidemiology)</term><term>Encephalitis, Viral (pathology)</term><term>Encephalitis, Viral (virology)</term><term>Falconiformes (MeSH)</term><term>Germany (epidemiology)</term><term>Influenza A Virus, H5N1 Subtype (physiology)</term><term>Influenza in Birds (complications)</term><term>Influenza in Birds (epidemiology)</term><term>Influenza in Birds (pathology)</term><term>Polymerase Chain Reaction (veterinary)</term><term>Trachea (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allemagne (épidémiologie)</term><term>Animaux (MeSH)</term><term>Cloaque (virologie)</term><term>Encéphalite virale (anatomopathologie)</term><term>Encéphalite virale (virologie)</term><term>Encéphalite virale (épidémiologie)</term><term>Falconiformes (MeSH)</term><term>Grippe chez les oiseaux (anatomopathologie)</term><term>Grippe chez les oiseaux (complications)</term><term>Grippe chez les oiseaux (épidémiologie)</term><term>Réaction de polymérisation en chaîne (médecine vétérinaire)</term><term>Sous-type H5N1 du virus de la grippe A (physiologie)</term><term>Trachée (virologie)</term><term>Épidémies de maladies (médecine vétérinaire)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphalite virale</term><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Encephalitis, Viral</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Réaction de polymérisation en chaîne</term><term>Épidémies de maladies</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Encephalitis, Viral</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Disease Outbreaks</term><term>Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cloaque</term><term>Encéphalite virale</term><term>Trachée</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cloaca</term><term>Encephalitis, Viral</term><term>Trachea</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Encéphalite virale</term><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Falconiformes</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Falconiformes</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Raptors may contract highly pathogenic avian influenza virus H5N1 by hunting or scavenging infected prey. However, natural H5N1 infection in raptors is rarely reported. Therefore, we tested raptors found dead during an H5N1 outbreak in wild waterbirds in Mecklenburg-Western Pomerania, Germany, in 2006 for H5N1-associated disease. We tested 624 raptors of nine species-common buzzard (385), Eurasian sparrowhawk (111), common kestrel (38), undetermined species of buzzard (36), white-tailed sea eagle (19), undetermined species of raptor (12), northern goshawk (10), peregrine falcon (6), red kite (3), rough-legged buzzard (3), and western marsh-harrier (1)-for H5N1 infection in tracheal or combined tracheal/cloacal swabs of all birds, and on major tissues of all white-tailed sea eagles. H5N1 infection was detected in two species: common buzzard (12 positive, 3.1%) and peregrine falcon (2 positive, 33.3%). In all necropsied birds (both peregrine falcons and the six freshest common buzzards), H5N1 was found most consistently and at the highest concentration in the brain, and the main H5N1-associated lesion was marked non-suppurative encephalitis. Other H5N1-associated lesions occurred in air sac, lung, oviduct, heart, pancreas, coelomic ganglion, and adrenal gland. Our results show that the main cause of death in H5N1-positive raptors was encephalitis. Our results imply that H5N1 outbreaks in wild waterbirds are more likely to lead to exposure to and mortality from H5N1 in raptors that hunt or scavenge medium-sized birds, such as common buzzards and peregrine falcons, than in raptors that hunt small birds and do not scavenge, such as Eurasian sparrowhawks and common kestrels. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25879698</PMID><DateCompleted><Year>2015</Year><Month>11</Month><Day>17</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1297-9716</ISSN><JournalIssue CitedMedium="Internet"><Volume>46</Volume><PubDate><Year>2015</Year><Month>Mar</Month><Day>05</Day></PubDate></JournalIssue><Title>Veterinary research</Title><ISOAbbreviation>Vet. Res.</ISOAbbreviation></Journal><ArticleTitle>Host-specific exposure and fatal neurologic disease in wild raptors from highly pathogenic avian influenza virus H5N1 during the 2006 outbreak in Germany.</ArticleTitle><Pagination><MedlinePgn>24</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13567-015-0148-5</ELocationID><Abstract><AbstractText>Raptors may contract highly pathogenic avian influenza virus H5N1 by hunting or scavenging infected prey. However, natural H5N1 infection in raptors is rarely reported. Therefore, we tested raptors found dead during an H5N1 outbreak in wild waterbirds in Mecklenburg-Western Pomerania, Germany, in 2006 for H5N1-associated disease. We tested 624 raptors of nine species-common buzzard (385), Eurasian sparrowhawk (111), common kestrel (38), undetermined species of buzzard (36), white-tailed sea eagle (19), undetermined species of raptor (12), northern goshawk (10), peregrine falcon (6), red kite (3), rough-legged buzzard (3), and western marsh-harrier (1)-for H5N1 infection in tracheal or combined tracheal/cloacal swabs of all birds, and on major tissues of all white-tailed sea eagles. H5N1 infection was detected in two species: common buzzard (12 positive, 3.1%) and peregrine falcon (2 positive, 33.3%). In all necropsied birds (both peregrine falcons and the six freshest common buzzards), H5N1 was found most consistently and at the highest concentration in the brain, and the main H5N1-associated lesion was marked non-suppurative encephalitis. Other H5N1-associated lesions occurred in air sac, lung, oviduct, heart, pancreas, coelomic ganglion, and adrenal gland. Our results show that the main cause of death in H5N1-positive raptors was encephalitis. Our results imply that H5N1 outbreaks in wild waterbirds are more likely to lead to exposure to and mortality from H5N1 in raptors that hunt or scavenge medium-sized birds, such as common buzzards and peregrine falcons, than in raptors that hunt small birds and do not scavenge, such as Eurasian sparrowhawks and common kestrels. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van den Brand</LastName><ForeName>Judith Ma</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. j.vandenbrand@erasmusmc.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krone</LastName><ForeName>Oliver</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Straße 17, 10315, Berlin, Germany. KRONE@izw-berlin.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolf</LastName><ForeName>Peter U</ForeName><Initials>PU</Initials><AffiliationInfo><Affiliation>Department for Diagnostic Investigation of Epizootics (LALLF), State Office for Agriculture, Food Safety, and Fishery, Mecklenburg-Western Pomerania, Rostock, Germany. Peter.Wolf@lallf.mvnet.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van de Bildt</LastName><ForeName>Marco W G</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. m.vandebildt@erasmusmc.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Amerongen</LastName><ForeName>Geert</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. amerongen@viroclinics.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Osterhaus</LastName><ForeName>Albert D M E</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. a.osterhaus@erasmusmc.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuiken</LastName><ForeName>Thijs</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE, Rotterdam, Netherlands. t.kuiken@erasmusmc.nl.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Vet Res</MedlineTA><NlmUniqueID>9309551</NlmUniqueID><ISSNLinking>0928-4249</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002988" MajorTopicYN="N">Cloaca</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018792" MajorTopicYN="N">Encephalitis, Viral</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D046093" MajorTopicYN="Y">Falconiformes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053124" MajorTopicYN="N">Influenza A Virus, H5N1 Subtype</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014132" MajorTopicYN="N">Trachea</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>09</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>01</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>4</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>4</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>11</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25879698</ArticleId><ArticleId IdType="doi">10.1186/s13567-015-0148-5</ArticleId><ArticleId IdType="pii">10.1186/s13567-015-0148-5</ArticleId><ArticleId IdType="pmc">PMC4349770</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Vet Pathol. 2007 Mar;44(2):137-43</Citation><ArticleIdList><ArticleId IdType="pubmed">17317790</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2012 Apr;86(7):3975-84</Citation><ArticleIdList><ArticleId IdType="pubmed">22278228</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2009;4(10):e7555</Citation><ArticleIdList><ArticleId IdType="pubmed">19847294</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Virol. 2009 Jan 1;2009:1</Citation><ArticleIdList><ArticleId IdType="pubmed">20148178</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2005 Jul 14;436(7048):191-2</Citation><ArticleIdList><ArticleId IdType="pubmed">16007072</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2005 Aug 19;309(5738):1206</Citation><ArticleIdList><ArticleId IdType="pubmed">16000410</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2012 Jan;86(2):1158-65</Citation><ArticleIdList><ArticleId IdType="pubmed">22090101</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2012 Oct;18(10):1596-602</Citation><ArticleIdList><ArticleId IdType="pubmed">23017273</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2006 Nov;12(11):1663-70</Citation><ArticleIdList><ArticleId IdType="pubmed">17283615</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2009 Mar 1;199(5):717-25</Citation><ArticleIdList><ArticleId IdType="pubmed">19210164</ArticleId></ArticleIdList></Reference><Reference><Citation>Vet Pathol. 2012 May;49(3):562-8</Citation><ArticleIdList><ArticleId IdType="pubmed">22262355</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2009 Oct;15(10):1633-6</Citation><ArticleIdList><ArticleId IdType="pubmed">19861060</ArticleId></ArticleIdList></Reference><Reference><Citation>Vet Pathol. 2010 Sep;47(5):893-914</Citation><ArticleIdList><ArticleId IdType="pubmed">20682805</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2012;7(3):e32107</Citation><ArticleIdList><ArticleId IdType="pubmed">22427819</ArticleId></ArticleIdList></Reference><Reference><Citation>Avian Dis. 2012 Mar;56(1):144-52</Citation><ArticleIdList><ArticleId IdType="pubmed">22545540</ArticleId></ArticleIdList></Reference><Reference><Citation>Influenza Other Respir Viruses. 2010 Nov;4(6):379-86</Citation><ArticleIdList><ArticleId IdType="pubmed">20958932</ArticleId></ArticleIdList></Reference><Reference><Citation>J Vet Med Sci. 2010 Apr;72(4):459-63</Citation><ArticleIdList><ArticleId IdType="pubmed">20009423</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2008 Apr;14(4):600-7</Citation><ArticleIdList><ArticleId IdType="pubmed">18394278</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol Methods. 1998 Sep;74(1):57-66</Citation><ArticleIdList><ArticleId IdType="pubmed">9763129</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2005 May;11(5):702-5</Citation><ArticleIdList><ArticleId IdType="pubmed">15890123</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2004 Oct 8;306(5694):241</Citation><ArticleIdList><ArticleId IdType="pubmed">15345779</ArticleId></ArticleIdList></Reference><Reference><Citation>Rev Sci Tech. 2009 Apr;28(1):113-36</Citation><ArticleIdList><ArticleId IdType="pubmed">19618622</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Microbiol. 2002 Sep;40(9):3256-60</Citation><ArticleIdList><ArticleId IdType="pubmed">12202562</ArticleId></ArticleIdList></Reference><Reference><Citation>Vet Microbiol. 2008 Apr 30;128(3-4):243-52</Citation><ArticleIdList><ArticleId IdType="pubmed">18031958</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2011 May;85(10):4673-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21411541</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Pays-Bas</li></country><region><li>Berlin</li><li>Hollande-Méridionale</li></region><settlement><li>Berlin</li><li>Rotterdam</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Den Brand, Judith Ma" sort="Van Den Brand, Judith Ma" uniqKey="Van Den Brand J" first="Judith Ma" last="Van Den Brand">Judith Ma Van Den Brand</name></region><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name><name sortKey="Van De Bildt, Marco W G" sort="Van De Bildt, Marco W G" uniqKey="Van De Bildt M" first="Marco W G" last="Van De Bildt">Marco W G. Van De Bildt</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Krone, Oliver" sort="Krone, Oliver" uniqKey="Krone O" first="Oliver" last="Krone">Oliver Krone</name></region><name sortKey="Wolf, Peter U" sort="Wolf, Peter U" uniqKey="Wolf P" first="Peter U" last="Wolf">Peter U. Wolf</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeAllemagneV4/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000136 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000136 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= GrippeAllemagneV4
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25879698
|texte= Host-specific exposure and fatal neurologic disease in wild raptors from highly pathogenic avian influenza virus H5N1 during the 2006 outbreak in Germany.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25879698" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeAllemagneV4
| This area was generated with Dilib version V0.6.35. |  |